Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays anticancer effects on several types of can...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Niu, Ning-Kui, Wang, Zi-Li, Pan, Shu-Ting, Ding, Hui-Qiang, Au, Giang HT, He, Zhi-Xu, Zhou, Zhi-Wei, Xiao, Guozhi, Yang, Yin-Xue, Zhang, Xueji, Yang, Tianxin, Chen, Xiao-Wu, Qiu, Jia-Xuan, Zhou, Shu-Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2015
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362906/
https://ncbi.nlm.nih.gov/pubmed/25792811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S74197
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