EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling

Pulmonary arterial hypertension (PAH) is commonly associated with chronic hypoxemia in disorders such as chronic obstructive pulmonary disease (COPD). Prostacyclin analogs are widely used in the management of PAH patients; however, clinical efficacy and long-term tolerability of some prostacyclin an...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lu, Ankang, Zuo, Caojian, He, Yuhu, Chen, Guilin, Piao, Lingjuan, Zhang, Jian, Xiao, Bing, Shen, Yujun, Tang, Juan, Kong, Deping, Alberti, Sara, Chen, Di, Zuo, Shenkai, Zhang, Qianqian, Yan, Shuai, Fei, Xiaochun, Yuan, Fei, Zhou, Bin, Duan, Shengzhong, Yu, Yu, Lazarus, Michael, Su, Yunchao, Breyer, Richard M., Funk, Colin D., Yu, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362262/
https://ncbi.nlm.nih.gov/pubmed/25664856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77656
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