Fingolimod Prevents Blood-Brain Barrier Disruption Induced by the Sera from Patients with Multiple Sclerosis

OBJECTIVE: Effect of fingolimod in multiple sclerosis (MS) is thought to involve the prevention of lymphocyte egress from lymphoid tissues, thereby reducing autoaggressive lymphocyte infiltration into the central nervous system across blood-brain barrier (BBB). However, brain microvascular endotheli...

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Udgivet i:PLoS One
Main Authors: Nishihara, Hideaki, Shimizu, Fumitaka, Sano, Yasuteru, Takeshita, Yukio, Maeda, Toshihiko, Abe, Masaaki, Koga, Michiaki, Kanda, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361641/
https://ncbi.nlm.nih.gov/pubmed/25774903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121488
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