Markedly Increased IP-10 Production by Blood-Brain Barrier in Neuromyelitis Optica

OBJECTIVE: Severe damage to the blood-brain barrier (BBB) allows anti-aquaporin 4 (AQP4) antibodies to access the astrocytic endfeet in neuromyelitis optica (NMO). In the current study, we identified the pathogenic cytokines/chemokines that are responsible for the BBB malfunction induced by NMO sera...

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Veröffentlicht in:PLoS One
Hauptverfasser: Shimizu, Fumitaka, Nishihara, Hideaki, Sano, Yasuteru, Takeshita, Yukio, Takahashi, Shiori, Maeda, Toshihiko, Takahashi, Toshiyuki, Abe, Masaaki, Koga, Michiaki, Kanda, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374747/
https://ncbi.nlm.nih.gov/pubmed/25811465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122000
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