Increasing the Structural Coverage of Tuberculosis Drug Targets

High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus “homolog-rescue” strategy to increase the structural information...

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Publicado en:Tuberculosis (Edinb)
Main Authors: Baugh, Loren, Phan, Isabelle, Begley, Darren W., Clifton, Matthew C., Armour, Brianna, Dranow, David M., Taylor, Brandy M., Muruthi, Marvin M., Abendroth, Jan, Fairman, James W., Fox, David, Dieterich, Shellie H., Staker, Bart L., Gardberg, Anna S., Choi, Ryan, Hewitt, Stephen N., Napuli, Alberto J., Myers, Janette, Barrett, Lynn K., Zhang, Yang, Ferrell, Micah, Mundt, Elizabeth, Thompkins, Katie, Tran, Ngoc, Lyons-Abbott, Sally, Abramov, Ariel, Sekar, Aarthi, Serbzhinskiy, Dmitri, Lorimer, Don, Buchko, Garry W., Stacy, Robin, Stewart, Lance J., Edwards, Thomas E., Van Voorhis, Wesley C., Myler, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361283/
https://ncbi.nlm.nih.gov/pubmed/25613812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2014.12.003
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