Increasing the Structural Coverage of Tuberculosis Drug Targets

High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus “homolog-rescue” strategy to increase the structural information...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Tuberculosis (Edinb)
Main Authors: Baugh, Loren, Phan, Isabelle, Begley, Darren W., Clifton, Matthew C., Armour, Brianna, Dranow, David M., Taylor, Brandy M., Muruthi, Marvin M., Abendroth, Jan, Fairman, James W., Fox, David, Dieterich, Shellie H., Staker, Bart L., Gardberg, Anna S., Choi, Ryan, Hewitt, Stephen N., Napuli, Alberto J., Myers, Janette, Barrett, Lynn K., Zhang, Yang, Ferrell, Micah, Mundt, Elizabeth, Thompkins, Katie, Tran, Ngoc, Lyons-Abbott, Sally, Abramov, Ariel, Sekar, Aarthi, Serbzhinskiy, Dmitri, Lorimer, Don, Buchko, Garry W., Stacy, Robin, Stewart, Lance J., Edwards, Thomas E., Van Voorhis, Wesley C., Myler, Peter J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361283/
https://ncbi.nlm.nih.gov/pubmed/25613812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2014.12.003
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