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Mitochondria-derived ROS bursts disturb Ca(2+) cycling and induce abnormal automaticity in guinea pig cardiomyocytes: a theoretical study
Mitochondria are in close proximity to the redox-sensitive sarcoplasmic reticulum (SR) Ca(2+) release [ryanodine receptors (RyRs)] and uptake [Ca(2+)-ATPase (SERCA)] channels. Thus mitochondria-derived reactive oxygen species (mdROS) could play a crucial role in modulating Ca(2+) cycling in the card...
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Publicado no: | Am J Physiol Heart Circ Physiol |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360058/ https://ncbi.nlm.nih.gov/pubmed/25539710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00493.2014 |
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