Flow regulation of endothelin-1 production in the inner medullary collecting duct

Collecting duct-derived endothelin (ET)-1 is an autocrine inhibitor of Na(+) and water reabsorption; its deficiency causes hypertension and water retention. Extracellular fluid volume expansion increases collecting duct ET-1, thereby promoting natriuresis and diuresis; however, how this coupling bet...

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Bibliographic Details
Published in:Am J Physiol Renal Physiol
Main Authors: Pandit, Meghana M., Inscho, Edward W., Zhang, Shali, Seki, Tsugio, Rohatgi, Rajeev, Gusella, Luca, Kishore, Bellamkonda, Kohan, Donald E.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360032/
https://ncbi.nlm.nih.gov/pubmed/25587122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00456.2014
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