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Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells

Short-term starvation or fasting can augment cancer treatment efficacy and can be effective in delaying cancer progression in the absence of chemotherapy, but the underlying molecular mechanisms of action remain elusive. Here we describe the role of REV1, a specialized DNA polymerase involved in DNA...

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Publicado en:Cancer Res
Autores principales: Shim, Hong Seok, Wei, Min, Brandhorst, Sebastian, Longo, Valter D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359966/
https://ncbi.nlm.nih.gov/pubmed/25614517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2249
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