Effective Targeting of the P53/MDM2 Axis in Preclinical Models of Infant MLL-Rearranged Acute Lymphoblastic Leukemia

PURPOSE: While the overall cure rate for pediatric acute lymphoblastic leukemia (ALL) approaches 90%, infants with ALL harboring translocations in the mixed-lineage leukemia (MLL) oncogene (infant MLL-ALL) experience shorter remission duration and lower survival rates (∼50%). Mutations in the p53 tu...

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Publicado no:Clin Cancer Res
Main Authors: Richmond, Jennifer, Carol, Hernan, Evans, Kathryn, High, Laura, Mendomo, Agnes, Robbins, Alissa, Meyer, Claus, Venn, Nicola C., Marschalek, Rolf, Henderson, Michelle, Sutton, Rosemary, Kurmasheva, Raushan T., Kees, Ursula R., Houghton, Peter J., Smith, Malcolm A., Lock, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359964/
https://ncbi.nlm.nih.gov/pubmed/25573381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2300
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