Interferon Regulatory Factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate

Interferon regulatory factor-1 (IRF1) is a tumor suppressor that regulates cell fate in several cell types. Here we report an inverse correlation in expression of nuclear IRF1 and the autophagy regulator ATG7 in human breast cancer cells that directly impacts their cell fate. In mice harboring mutan...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Schwartz-Roberts, Jessica L., Cook, Katherine L., Chen, Chun, Shajahan-Haq, Ayesha N., Axelrod, Margaret, Wärri, Anni, Riggins, Rebecca B., Jin, Lu, Haddad, Bassem R., Kallakury, Bhaskar V., Baumann, William T., Clarke, Robert
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359953/
https://ncbi.nlm.nih.gov/pubmed/25576084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1851
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