Interferon Regulatory Factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate

Interferon regulatory factor-1 (IRF1) is a tumor suppressor that regulates cell fate in several cell types. Here we report an inverse correlation in expression of nuclear IRF1 and the autophagy regulator ATG7 in human breast cancer cells that directly impacts their cell fate. In mice harboring mutan...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Schwartz-Roberts, Jessica L., Cook, Katherine L., Chen, Chun, Shajahan-Haq, Ayesha N., Axelrod, Margaret, Wärri, Anni, Riggins, Rebecca B., Jin, Lu, Haddad, Bassem R., Kallakury, Bhaskar V., Baumann, William T., Clarke, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359953/
https://ncbi.nlm.nih.gov/pubmed/25576084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1851
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