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Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods to delineate the mechanism of the homotrimeric RND...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4359379/ https://ncbi.nlm.nih.gov/pubmed/25248080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03145 |
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