Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level

Glioblastoma Multiforme (GBM), the most common and lethal adult primary tumor of the brain, showed a link between Sonic Hedgehog (SHH) pathway in the resistance to temozolomide (TMZ). PTCH1, the SHH receptor, can tonically represses signaling by endocytosis. We asked how the decrease in PTCH1 in GBM...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Munoz, Jessian L., Rodriguez-Cruz, Vivian, Ramkissoon, Shakti H., Ligon, Keith L., Greco, Steven J., Rameshwar, Pranela
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359226/
https://ncbi.nlm.nih.gov/pubmed/25595896
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