Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide (TMZ). As the connexins (Cx) have been shown to have a complex role in GBM, we investigated the role of Cx43 in TMZ resistance. Cx...

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Bibliografiset tiedot
Päätekijät: Munoz, J L, Rodriguez-Cruz, V, Greco, S J, Ramkissoon, S H, Ligon, K L, Rameshwar, P
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2014
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973225/
https://ncbi.nlm.nih.gov/pubmed/24675463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.111
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