Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide (TMZ). As the connexins (Cx) have been shown to have a complex role in GBM, we investigated the role of Cx43 in TMZ resistance. Cx...

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Detalhes bibliográficos
Main Authors: Munoz, J L, Rodriguez-Cruz, V, Greco, S J, Ramkissoon, S H, Ligon, K L, Rameshwar, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973225/
https://ncbi.nlm.nih.gov/pubmed/24675463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.111
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