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Comparative Metabolic Analysis of CHO Cell Clones Obtained through Cell Engineering, for IgG Productivity, Growth and Cell Longevity

Cell engineering has been used to improve animal cells’ central carbon metabolism. Due to the central carbon metabolism’s inefficiency and limiting input of carbons into the TCA cycle, key reactions belonging to these pathways have been targeted to improve cultures’ performance. Previous works have...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Wilkens, Camila A., Gerdtzen, Ziomara P.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358941/
https://ncbi.nlm.nih.gov/pubmed/25768021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119053
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