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The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes

Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic rec...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Pacheco, Sarai, Marcet-Ortega, Marina, Lange, Julian, Jasin, Maria, Keeney, Scott, Roig, Ignasi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358828/
https://ncbi.nlm.nih.gov/pubmed/25768017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005017
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