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The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes

Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic rec...

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Publicat a:PLoS Genet
Autors principals: Pacheco, Sarai, Marcet-Ortega, Marina, Lange, Julian, Jasin, Maria, Keeney, Scott, Roig, Ignasi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358828/
https://ncbi.nlm.nih.gov/pubmed/25768017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005017
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