p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes

To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex—ATM—CHK2 pathway respon...

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Udgivet i:PLoS Genet
Main Authors: Marcet-Ortega, Marina, Pacheco, Sarai, Martínez-Marchal, Ana, Castillo, Helena, Flores, Elsa, Jasin, Maria, Keeney, Scott, Roig, Ignasi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491309/
https://ncbi.nlm.nih.gov/pubmed/28617799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006845
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