Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer’s disease

Presenilins play essential roles in memory formation, synaptic function, and neuronal survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial Alzheimer’s disease (FAD). How PSEN1 mutations cause FAD is unclear, and pathogenic mechanisms based on gain or loss of function...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Neuron
Asıl Yazarlar: Xia, Dan, Watanabe, Hirotaka, Wu, Bei, Lee, Sang Hun, Li, Yan, Tsvetkov, Evgeny, Bolshakov, Vadim Y., Shen, Jie, Kelleher, Raymond J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358812/
https://ncbi.nlm.nih.gov/pubmed/25741723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.02.010
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller