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Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer’s disease
Presenilins play essential roles in memory formation, synaptic function, and neuronal survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial Alzheimer’s disease (FAD). How PSEN1 mutations cause FAD is unclear, and pathogenic mechanisms based on gain or loss of function...
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| Veröffentlicht in: | Neuron |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4358812/ https://ncbi.nlm.nih.gov/pubmed/25741723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.02.010 |
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