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Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity

Mutations in the Presenilin genes are the major genetic cause of Alzheimer's disease (AD). Presenilin (PS) is highly expressed in the hippocampus, which is particularly vulnerable in AD. Previous studies of PS function in the hippocampus, however, focused exclusively on excitatory neurons. Whet...

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Publicado en:Mol Brain
Main Authors: Lee, Sang Hun, Bolshakov, Vadim Y., Shen, Jie
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152317/
https://ncbi.nlm.nih.gov/pubmed/34034776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-021-00796-5
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