Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

Abstract Background Presenilins play a major role in the pathogenesis of Alzheimer’s disease, in which the hippocampus is particularly vulnerable. Previous studies of Presenilin function in the synapse, however, focused exclusively on the hippocampal Schaffer collateral (SC) pathway. Whether Preseni...

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Detalhes bibliográficos
Main Authors: Sang Hun Lee, David Lutz, Mohanad Mossalam, Vadim Y. Bolshakov, Michael Frotscher, Jie Shen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-06-01
Colecção:Molecular Neurodegeneration
Assuntos:
Presenilin
Mossy fiber
Synaptic plasticity
Mitochondria
Calcium
Acesso em linha:http://link.springer.com/article/10.1186/s13024-017-0189-5
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