Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

Abstract Background Presenilins play a major role in the pathogenesis of Alzheimer’s disease, in which the hippocampus is particularly vulnerable. Previous studies of Presenilin function in the synapse, however, focused exclusively on the hippocampal Schaffer collateral (SC) pathway. Whether Preseni...

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Autori principali: Sang Hun Lee, David Lutz, Mohanad Mossalam, Vadim Y. Bolshakov, Michael Frotscher, Jie Shen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2017-06-01
Serie:Molecular Neurodegeneration
Soggetti:
Presenilin
Mossy fiber
Synaptic plasticity
Mitochondria
Calcium
Accesso online:http://link.springer.com/article/10.1186/s13024-017-0189-5
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