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The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
Dominantly inherited mutations in the genes encoding presenilins (PS) and the amyloid precursor protein (APP) are the major causes of familial Alzheimer's disease (AD). The prevailing view of AD pathogenesis posits that accumulation of β-amyloid (Aβ) peptides, particularly Aβ42, is the central...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1766397/ https://ncbi.nlm.nih.gov/pubmed/17197420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608332104 |
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