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The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
Dominantly inherited mutations in the genes encoding presenilins (PS) and the amyloid precursor protein (APP) are the major causes of familial Alzheimer's disease (AD). The prevailing view of AD pathogenesis posits that accumulation of β-amyloid (Aβ) peptides, particularly Aβ42, is the central...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1766397/ https://ncbi.nlm.nih.gov/pubmed/17197420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608332104 |
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