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The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism

Dominantly inherited mutations in the genes encoding presenilins (PS) and the amyloid precursor protein (APP) are the major causes of familial Alzheimer's disease (AD). The prevailing view of AD pathogenesis posits that accumulation of β-amyloid (Aβ) peptides, particularly Aβ42, is the central...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shen, Jie, Kelleher, Raymond J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2007
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766397/
https://ncbi.nlm.nih.gov/pubmed/17197420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608332104
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