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Loss of Aβ43 production caused by Presenilin-1 mutations in the knockin mouse brain
We recently reported that homozygous Presenilin-1 (Psen1) knockin (KI) mice carrying the familial Alzheimer’s disease (FAD) mutation L435F or C410Y recapitulate the phenotypes of Psen1(−/−) mice. Production and steady-state levels of Aβ40 and Aβ42 are undetectable in KI/KI brains and reduced in KI/+...
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| Publicado no: | Neuron |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4840410/ https://ncbi.nlm.nih.gov/pubmed/27100200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.03.009 |
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