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Radioprotective efficacy and toxicity of a new family of aminothiol analogs

PURPOSE: A family of 17 new nucleophilic-polyamine and aminothiol structures was designed and synthesized to identify new topical or systemic radioprotectors with acceptable mammalian toxicity profiles. Design elements included: (i) Length and charge of the DNA-interacting, alkylamine backbone, (ii)...

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Vydáno v:Int J Radiat Biol
Hlavní autoři: Copp, Richard R., Peebles, Daniel D., Soref, Cheryl M., Fahl, William E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358772/
https://ncbi.nlm.nih.gov/pubmed/23369131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/09553002.2013.770579
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