Evidence for Restricted Reactivity of ADAMDEC1 with Protein Substrates and Endogenous Inhibitors

ADAMDEC1 is a proteolytically active metzincin metalloprotease displaying rare active site architecture with a zinc-binding Asp residue (Asp-362). We previously demonstrated that substitution of Asp-362 for a His residue, thereby reconstituting the canonical metzincin zinc-binding environment with t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Lund, Jacob, Troeberg, Linda, Kjeldal, Henrik, Olsen, Ole H., Nagase, Hideaki, Sørensen, Esben S., Stennicke, Henning R., Petersen, Helle H., Overgaard, Michael T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358294/
https://ncbi.nlm.nih.gov/pubmed/25564618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.601724
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