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A Parallel Quadruplex DNA Is Bound Tightly but Unfolded Slowly by Pif1 Helicase
DNA sequences that can form intramolecular quadruplex structures are found in promoters of proto-oncogenes. Many of these sequences readily fold into parallel quadruplexes. Here we characterize the ability of yeast Pif1 to bind and unfold a parallel quadruplex DNA substrate. We found that Pif1 binds...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4358282/ https://ncbi.nlm.nih.gov/pubmed/25589786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630749 |
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