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A Parallel Quadruplex DNA Is Bound Tightly but Unfolded Slowly by Pif1 Helicase

DNA sequences that can form intramolecular quadruplex structures are found in promoters of proto-oncogenes. Many of these sequences readily fold into parallel quadruplexes. Here we characterize the ability of yeast Pif1 to bind and unfold a parallel quadruplex DNA substrate. We found that Pif1 binds...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Byrd, Alicia K., Raney, Kevin D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358282/
https://ncbi.nlm.nih.gov/pubmed/25589786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630749
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