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Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death

Autophagy, a cellular recycling process responsible for turnover of cytoplasmic contents, is critical for maintenance of health. Defects in this process have been linked to diabetes. Diabetes-associated glucotoxicity/lipotoxicity contribute to impaired β-cell function and have been implicated as con...

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Опубликовано в: :J Biol Chem
Главные авторы: Mir, Shakeel U. R., George, Nicholas M., Zahoor, Lubna, Harms, Robert, Guinn, Zachary, Sarvetnick, Nora E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358249/
https://ncbi.nlm.nih.gov/pubmed/25548282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.605345
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