Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus

Calcineurin is a key protein phosphatase required for hyphal growth and virulence in Aspergillus fumigatus, making it an attractive antifungal target. However, currently available calcineurin inhibitors, FK506 and cyclosporine A, are immunosuppressive, limiting usage in the treatment of patients wit...

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Bibliografiska uppgifter
I publikationen:Front Microbiol
Huvudupphovsmän: Juvvadi, Praveen R., Ma, Yan, Richards, Amber D., Soderblom, Erik J., Moseley, M. Arthur, Lamoth, Frédéric, Steinbach, William J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2015
Ämnen:
Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358225/
https://ncbi.nlm.nih.gov/pubmed/25821446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00175
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