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Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus

The echinocandin antifungal drug caspofungin at high concentrations reverses the growth inhibition of Aspergillus fumigatus, a phenomenon known as the “paradoxical effect,” which is not consistently observed with other echinocandins (micafungin and anidulafungin). Previous studies of A. fumigatus re...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Juvvadi, Praveen R., Muñoz, Alberto, Lamoth, Frédéric, Soderblom, Erik J., Moseley, M. Arthur, Read, Nick D., Steinbach, William J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505252/
https://ncbi.nlm.nih.gov/pubmed/26055379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00263-15
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