Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to Caspofungin

Attenuated activity of echinocandin antifungals at high concentrations, known as the “paradoxical effect,” is a well-established phenomenon in Candida albicans and Aspergillus fumigatus. In the yeast C. albicans, upregulation of chitin biosynthesis via the protein kinase C (PKC), high-osmolarity gly...

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Bibliografiset tiedot
Päätekijät: Fortwendel, Jarrod R., Juvvadi, Praveen R., Perfect, B. Zachary, Rogg, Luise E., Perfect, John R., Steinbach, William J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2010
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Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849361/
https://ncbi.nlm.nih.gov/pubmed/20124000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00854-09
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