Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus

Calcineurin is a key protein phosphatase required for hyphal growth and virulence in Aspergillus fumigatus, making it an attractive antifungal target. However, currently available calcineurin inhibitors, FK506 and cyclosporine A, are immunosuppressive, limiting usage in the treatment of patients wit...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Juvvadi, Praveen R., Ma, Yan, Richards, Amber D., Soderblom, Erik J., Moseley, M. Arthur, Lamoth, Frédéric, Steinbach, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358225/
https://ncbi.nlm.nih.gov/pubmed/25821446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00175
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