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Exposure of Neutralizing Epitopes in the Carboxyl-terminal Domain of TcdB Is Altered by a Proximal Hypervariable Region

The sequence, activity, and antigenicity of TcdB varies between different strains of Clostridium difficile. As a result, ribotype-specific forms of TcdB exhibit different toxicities and are not strongly cross-neutralized. Using a combination of biochemical and immunological approaches, we compared t...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Larabee, Jason L., Krumholz, Aleze, Hunt, Jonathan J., Lanis, Jordi M., Ballard, Jimmy D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358121/
https://ncbi.nlm.nih.gov/pubmed/25614625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612184
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