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Critical role of CD4 T cells in PF4/heparin antibody production in mice
Antibodies specific for platelet factor 4 (PF4)/heparin complexes are central to the pathogenesis of heparin-induced thrombocytopenia. Marginal zone B cells appear to be the source of such antibodies, but whether T-cell help is required is unclear. Here, we showed that induction of PF4/heparin-speci...
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| Publicado no: | Blood |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357587/ https://ncbi.nlm.nih.gov/pubmed/25595736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-603464 |
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