Critical role for mouse marginal zone B cells in PF4/heparin antibody production

Heparin-induced thrombocytopenia (HIT) is an immune-mediated disorder that can cause fatal arterial or venous thrombosis/thromboembolism. Immune complexes consisting of platelet factor 4 (PF4), heparin, and PF4/heparin-reactive antibodies are central to the pathogenesis of HIT. However, the B-cell o...

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Detalhes bibliográficos
Main Authors: Zheng, Yongwei, Yu, Mei, Podd, Andrew, Yuan, Liudi, Newman, Debra K., Wen, Renren, Arepally, Gowthami, Wang, Demin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637017/
https://ncbi.nlm.nih.gov/pubmed/23460609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-477091
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