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B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia
Immune complexes consisting of heparin, platelet factor 4 (PF4), and PF4/heparin-reactive antibodies are central to the pathogenesis of heparin-induced thrombocytopenia (HIT). It is as yet unclear what triggers the initial induction of pathogenic antibodies. We identified B cells in peripheral blood...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3916881/ https://ncbi.nlm.nih.gov/pubmed/24357731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-540781 |
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