B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia

Immune complexes consisting of heparin, platelet factor 4 (PF4), and PF4/heparin-reactive antibodies are central to the pathogenesis of heparin-induced thrombocytopenia (HIT). It is as yet unclear what triggers the initial induction of pathogenic antibodies. We identified B cells in peripheral blood...

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Detaylı Bibliyografya
Asıl Yazarlar: Zheng, Yongwei, Wang, Alexander W., Yu, Mei, Padmanabhan, Anand, Tourdot, Benjamin E., Newman, Debra K., White, Gilbert C., Aster, Richard H., Wen, Renren, Wang, Demin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2014
Konular:
Transfusion Medicine
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916881/
https://ncbi.nlm.nih.gov/pubmed/24357731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-11-540781
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