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Potent and specific peptide inhibitors of human pro-survival protein Bcl-x(L)
The Bcl-2 family of proteins plays a critical role regulating apoptosis, and pro-survival Bcl-2 family members are important therapeutic targets due to their overexpression in different cancers. Pro-apoptotic BH3-only proteins antagonize pro-survival Bcl-2 protein functions by binding directly to th...
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| Udgivet i: | J Mol Biol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357494/ https://ncbi.nlm.nih.gov/pubmed/25451027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.09.030 |
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