Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies

Generation of potent antibodies by a mutation-selection process called affinity maturation is a key component of effective immune responses. Antibodies that protect against highly mutable pathogens must neutralize diverse strains. Developing effective immunization strategies to drive their evolution...

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Publicado no:Cell
Main Authors: Wang, Shenshen, Mata-Fink, Jordi, Kriegsman, Barry, Hanson, Melissa, Irvine, Darrell J., Eisen, Herman N., Burton, Dennis R., Wittrup, K. Dane, Kardar, Mehran, Chakraborty, Arup K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357364/
https://ncbi.nlm.nih.gov/pubmed/25662010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.027
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