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The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation

The spikes on virus surfaces bind receptors on host cells to propagate infection. High spike densities (SDs) can promote infection, but spikes are also targets of antibody-mediated immune responses. Thus, diverse evolutionary pressures can influence virus SDs. HIV’s SD is about two orders of magnitu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Comput Biol
Prif Awduron: Amitai, Assaf, Chakraborty, Arup K., Kardar, Mehran
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150518/
https://ncbi.nlm.nih.gov/pubmed/30161121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006408
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