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The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation

The spikes on virus surfaces bind receptors on host cells to propagate infection. High spike densities (SDs) can promote infection, but spikes are also targets of antibody-mediated immune responses. Thus, diverse evolutionary pressures can influence virus SDs. HIV’s SD is about two orders of magnitu...

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Dades bibliogràfiques
Publicat a:PLoS Comput Biol
Autors principals: Amitai, Assaf, Chakraborty, Arup K., Kardar, Mehran
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150518/
https://ncbi.nlm.nih.gov/pubmed/30161121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006408
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