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Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives
We report the synthesis and biological evaluation of a new series of 8-oxoadenines substituted at the 9-position with a 4-piperidinylalkyl moiety. In vitro evaluation of the piperidinyl-substituted oxoadenines 3a–g in human TLR7- or TLR8-transfected HEK293 cells and in human PBMCs indicated that TLR...
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| Udgivet i: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357173/ https://ncbi.nlm.nih.gov/pubmed/25698055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.037 |
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