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The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3

The NR4A nuclear receptor family member Nr4a1 is strongly induced in thymocytes undergoing selection, and has been shown to control the development of T(reg) cells; however the role of Nr4a1 in CD8(+) T cells remains undefined. Here we report a novel role for Nr4a1 in regulating the development and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Nowyhed, Heba N., Huynh, Tridu R., Blatchley, Amy, Wu, Runpei, Thomas, Graham D., Hedrick, Catherine C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356985/
https://ncbi.nlm.nih.gov/pubmed/25762306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09059
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