RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation

T cell fate is associated with mutually exclusive expression of CD4 or CD8 in helper and cytotoxic T cells, respectively. How expression of one locus is temporally coordinated with repression of the other has been a long-standing enigma, though we know RUNX transcription factors activate the Cd8 loc...

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Main Authors: Collins, Amélie, Hewitt, Susannah L., Chaumeil, Julie, Sellars, MacLean, Micsinai, Mariann, Allinne, Jeanne, Parisi, Fabio, Nora, Elphège P., Bolland, Dan J., Corcoran, Anne E., Kluger, Yuval, Bosselut, Remy, Ellmeier, Wilfried, Chong, Mark M.W., Littman, Dan R., Skok, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101577/
https://ncbi.nlm.nih.gov/pubmed/21435585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.03.004
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