Variability of Voriconazole Plasma Concentrations after Allogeneic Hematopoietic Stem Cell Transplantation: Impact of Cytochrome P450 Polymorphisms and Comedications on Initial and Subsequent Trough Levels

Voriconazole (VRC) plasma trough concentrations (C(min)) are highly variable, and this could affect treatment efficacy and safety in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT). We aimed to describe the intra- and interindividual variation of VRC C(min) throughout...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Gautier-Veyret, Elodie, Fonrose, Xavier, Tonini, Julia, Thiebaut-Bertrand, Anne, Bartoli, Mireille, Quesada, Jean-Louis, Bulabois, Claude-Eric, Cahn, Jean-Yves, Stanke-Labesque, Françoise
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356835/
https://ncbi.nlm.nih.gov/pubmed/25645831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04838-14
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