Variability of Voriconazole Plasma Concentrations after Allogeneic Hematopoietic Stem Cell Transplantation: Impact of Cytochrome P450 Polymorphisms and Comedications on Initial and Subsequent Trough Levels

Voriconazole (VRC) plasma trough concentrations (C(min)) are highly variable, and this could affect treatment efficacy and safety in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT). We aimed to describe the intra- and interindividual variation of VRC C(min) throughout...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Gautier-Veyret, Elodie, Fonrose, Xavier, Tonini, Julia, Thiebaut-Bertrand, Anne, Bartoli, Mireille, Quesada, Jean-Louis, Bulabois, Claude-Eric, Cahn, Jean-Yves, Stanke-Labesque, Françoise
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356835/
https://ncbi.nlm.nih.gov/pubmed/25645831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04838-14
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