Variability of Voriconazole Plasma Concentrations after Allogeneic Hematopoietic Stem Cell Transplantation: Impact of Cytochrome P450 Polymorphisms and Comedications on Initial and Subsequent Trough Levels

Voriconazole (VRC) plasma trough concentrations (C(min)) are highly variable, and this could affect treatment efficacy and safety in patients undergoing allogeneic hematopoietic stem cell transplantation (AHSCT). We aimed to describe the intra- and interindividual variation of VRC C(min) throughout...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Gautier-Veyret, Elodie, Fonrose, Xavier, Tonini, Julia, Thiebaut-Bertrand, Anne, Bartoli, Mireille, Quesada, Jean-Louis, Bulabois, Claude-Eric, Cahn, Jean-Yves, Stanke-Labesque, Françoise
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356835/
https://ncbi.nlm.nih.gov/pubmed/25645831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04838-14
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