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Population Pharmacokinetic Modeling of Plasma and Intracellular Ribavirin Concentrations in Patients with Chronic Hepatitis C Virus Infection

Ribavirin, a guanosine analog, is a broad-spectrum antiviral agent. Ribavirin has been a fundamental component of the treatment of hepatitis C virus (HCV) infection for decades, but there is a very limited understanding of the clinical pharmacology of this drug. Furthermore, it is associated with a...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wu, Liviawati S., Rower, Joseph E., Burton, James R., Anderson, Peter L., Hammond, Kyle P., Baouchi-Mokrane, Fafa, Everson, Gregory T., Urban, Thomas J., D'Argenio, David Z., Kiser, Jennifer J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356818/
https://ncbi.nlm.nih.gov/pubmed/25645847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04618-14
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