HSV-1 Remodels Host Telomeres To Facilitate Viral Replication

Telomeres protect the ends of cellular chromosomes. We show here that infection with herpes simplex virus 1 (HSV-1) results in chromosomal structural aberrations at telomeres and the accumulation of telomere dysfunction-induced DNA damage foci (TIFs). At the molecular level, HSV-1 induces transcript...

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Publicat a:Cell Rep
Autors principals: Deng, Zhong, Kim, Eui Tae, Vladimirova, Olga, Dheekollu, Jayaraju, Wang, Zhuo, Newhart, Alyshia, Liu, Dongmei, Myers, Jaclyn L., Hensley, Scott E., Moffat, Jennifer, Janicki, Susan M., Fraser, Nigel W., Knipe, David M., Weitzman, Matthew D., Lieberman, Paul M.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356630/
https://ncbi.nlm.nih.gov/pubmed/25497088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.11.019
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