HSV-1 Remodels Host Telomeres To Facilitate Viral Replication

Telomeres protect the ends of cellular chromosomes. We show here that infection with herpes simplex virus 1 (HSV-1) results in chromosomal structural aberrations at telomeres and the accumulation of telomere dysfunction-induced DNA damage foci (TIFs). At the molecular level, HSV-1 induces transcript...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Deng, Zhong, Kim, Eui Tae, Vladimirova, Olga, Dheekollu, Jayaraju, Wang, Zhuo, Newhart, Alyshia, Liu, Dongmei, Myers, Jaclyn L., Hensley, Scott E., Moffat, Jennifer, Janicki, Susan M., Fraser, Nigel W., Knipe, David M., Weitzman, Matthew D., Lieberman, Paul M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356630/
https://ncbi.nlm.nih.gov/pubmed/25497088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.11.019
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