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Angiopoietin-1 Requires Oxidant Signaling through p47phox to Promote Endothelial Barrier Defense
BACKGROUND: Reactive oxygen species (ROS) are largely considered to be pathogenic to normal endothelial function in disease states such as sepsis. We hypothesized that Angiopoietin-1 (Angpt-1), an endogenous agonist of the endothelial-specific receptor, Tie-2, promotes barrier defense by activating...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356555/ https://ncbi.nlm.nih.gov/pubmed/25761062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119577 |
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